只是为了跟上George45的回答。经过各种调整，我发现以下是在Windows 10中去除平滑字体的最佳解决方案 - 除了某些Windows上存在的硬编码字体，如systemsettings.exe。
需要安装以下字体：serife.fon和sserife.fon（MS Sans Serif）。
备份注册表，然后将以下内容放入一个txt文件中，将其重命名为.reg并输入到注册表中。重新启动后，更改将生效。
REGEDIT4
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\FontSubstitutes]
"MS Shell Dlg"="MS Sans Serif"
"MS Shell Dlg 2"="Tahoma"
"Segoe UI"="MS Sans Serif"
"Segoe UI (TrueType)"="MS Sans Serif"
"Segoe UI Black"="MS Sans Serif"
"Segoe UI Black (TrueType)"="MS Sans Serif"
"Segoe UI Black Italic (TrueType)"="MS Sans Serif"
"Segoe UI Bold (TrueType)"="MS Sans Serif"
"Segoe UI Bold Italic (TrueType)"="MS Sans Serif"
"Segoe UI Historic (TrueType)"="MS Sans Serif"
"Segoe UI Italic (TrueType)"="MS Sans Serif"
"Segoe UI Light"="MS Sans Serif"
"Segoe UI Light (TrueType)"="MS Sans Serif"
"Segoe UI Light Italic (TrueType)"="MS Sans Serif"
"Segoe UI Semibold"="MS Sans Serif"
"Segoe UI Semibold (TrueType)"="MS Sans Serif"
"Segoe UI Semibold Italic (TrueType)"="MS Sans Serif"
"Segoe UI Semilight"="MS Sans Serif"
"Segoe UI Semilight (TrueType)"="MS Sans Serif"
"Segoe UI Semilight Italic (TrueType)"="MS Sans Serif"
"Arabic Transparent"="Arial"
"Arabic Transparent Bold"="Arial Bold"
"Arabic Transparent,0"="Arial,178"
"Arabic Transparent Bold,0"="Arial Bold,178"
"Helvetica"="Arial"
"Arial Baltic,186"="Arial,186"
"Arial CE,238"="Arial,238"
"Arial CYR,204"="Arial,204"
"Arial Greek,161"="Arial,161"
"Arial TUR,162"="Arial,162"
"Courier New Baltic,186"="Courier New,186"
"Courier New CE,238"="Courier New,238"
"Courier New CYR,204"="Courier New,204"
"Courier New Greek,161"="Courier New,161"
"Courier New TUR,162"="Courier New,162"
"Times"="Times New Roman"
"Times New Roman Baltic,186"="Times New Roman,186"
"Times New Roman CE,238"="Times New Roman,238"
"Times New Roman CYR,204"="Times New Roman,204"
"Times New Roman Greek,161"="Times New Roman,161"
"Times New Roman TUR,162"="Times New Roman,162"
"Tahoma Armenian"="Tahoma"
"Helv"="MS Sans Serif"
"Tms Rmn"="MS Serif"
"David Transparent"="David"
"Miriam Transparent"="Miriam"
"Fixed Miriam Transparent"="Miriam Fixed"
"Rod Transparent"="Rod"
"FangSong_GB2312"="FangSong"
"KaiTi_GB2312"="KaiTi"
[HKEY_LOCAL_MACHINE\SOFTWARE\Microsoft\Windows NT\CurrentVersion\Fonts]
"Segoe UI (TrueType)"=-
"Segoe UI Black (TrueType)"=-
"Segoe UI Black Italic (TrueType)"=-
"Segoe UI Bold (TrueType)"=-
"Segoe UI Bold Italic (TrueType)"=-
"Segoe UI Italic (TrueType)"=-
"Segoe UI Light (TrueType)"=-
"Segoe UI Light Italic (TrueType)"=-
"Segoe UI Semibold (TrueType)"=-
"Segoe UI Semibold Italic (TrueType)"=-
"Segoe UI Semilight (TrueType)"=-
"Segoe UI Semilight Italic (TrueType)"=-
[HKEY_CURRENT_USER\Software\Microsoft\Office\16.0\Common]
"RespectSystemFontSmooth"=dword:00000001
[HKEY_CURRENT_USER\Control Panel\Desktop]
"FontSmoothing"="0"
"FontSmoothingType"=dword:00000000
[HKEY_CURRENT_USER\Control Panel\Desktop\WindowMetrics]
"CaptionFont"=hex:f3,ff,ff,ff,00,00,00,00,00,00,00,00,00,00,00,00,90,01,00,00,\
00,00,00,cc,00,00,00,00,54,00,61,00,68,00,6f,00,6d,00,61,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00
"IconFont"=hex:f5,ff,ff,ff,00,00,00,00,00,00,00,00,00,00,00,00,90,01,00,00,\
00,00,00,cc,00,00,00,00,54,00,61,00,68,00,6f,00,6d,00,61,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00
"MenuFont"=hex:f4,ff,ff,ff,00,00,00,00,00,00,00,00,00,00,00,00,90,01,00,00,\
00,00,00,cc,00,00,00,00,54,00,61,00,68,00,6f,00,6d,00,61,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00
"MessageFont"=hex:f5,ff,ff,ff,00,00,00,00,00,00,00,00,00,00,00,00,90,01,00,00,\
00,00,00,cc,00,00,00,00,54,00,61,00,68,00,6f,00,6d,00,61,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00
"SmCaptionFont"=hex:f3,ff,ff,ff,00,00,00,00,00,00,00,00,00,00,00,00,90,01,00,\
00,00,00,00,cc,00,00,00,00,54,00,61,00,68,00,6f,00,6d,00,61,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00
"StatusFont"=hex:f5,ff,ff,ff,00,00,00,00,00,00,00,00,00,00,00,00,90,01,00,00,\
00,00,00,cc,00,00,00,00,54,00,61,00,68,00,6f,00,6d,00,61,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,\
00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00,00
您可以在下面尝试不同的字体：
"Segoe UI"="MS Sans Serif"
例子：
"Segoe UI"="WineTahomaBit"